📢 *⚠️ Why Should Enrofloxacin Be Avoided in Young Calves? 🐄🚫*
🔬 *How Enrofloxacin Damages Cartilage in Calves:*
🔹 *Drug Accumulation in Cartilage Cells (Chondrocytes) 🏗️* disrupting normal cell function.
🔹Inhibits *DNA gyrase & topoisomerase IV*, affecting chondrocyte division and repair.
🔹 *Proteoglycan & Collagen Depletion 🏗️➡️🦴* weakening cartilage.Leads to **soft, fragile, and easily damaged joints*.
🔹 Loss of chondrocytes results in *joint deformities & improper bone growth*.Can lead to
lameness and permanent joint damage in growing calves.
🚑 *Clinical Signs in Affected Calves:*
🐄 *Lameness & joint pain* 😢
🐄 *Joint swelling & difficulty walking* 🚶❌
🐄 *Arthritis & irreversible cartilage damage* ⚠️
🚫 *Avoid Enrofloxacin in Young Calves!* Use *safer alternatives** like:
✅
Beta-lactams (Penicillins, Cephalosporins) 💊
✅
Macrolides (Tulathromycin) 💉
*
https://chat.whatsapp.com/J7bQwemCt1kGHB3bsU4TYL*
