فوارق مهمة  تكدرون تستفادون منها بين furosemide و torasemide✅✅

🔴يعتبر Torasemide + furosemide من مجموعة loop diuretics
🔷MOA:
by reducing reabsorption of Na+
K+& Cl- at the thick ascending limb of henle loop.
🔸اهم الفوارق المهمة لازم نعرفها بين
torasemide & furosemide
🔺من ناحية potency :
torasemide tow times more potent than furosemide✅
🔺من ناحيةduration of Action  :
Torsemide has longer duration (12-16 hours) when compared to Furosemide (6-8 hours)✅
🔺من ناحية oral absorption :
Torsemide has a more rapid oral absorption (1 hour) tha Furosemide (2-3 hours)✅
🔺من ناحيةhalf life :
بالنسبة Torasemide 3-4h✅
بينما furosemide 1h✅
🔺من ناحية dose :
A dose of 40 mg of furosemide is equivalent to 20 mg of Torsemide✅
🔺من ناحيةbioavaliability :
torasemide :(80-100% )✅
furosemide :(10-100%)✅
🔺من ناحيةElimenation :
Torasemide:80%hepatic+20%renal✅
furosemide:50%hepatic+50%renal✅
🔺من ناحيةfood :
Torasemide not effect furosemide is effect ✅
🔺من ناحية مقارنةIV مع Oral :
Intravenous furosemide is (2-1)as oral ✅
Iv torasemide is 1:1 as oral ✅
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